马慧敏，特任研究员，硕士生导师。2009年毕业于中国科学院广州地球化学研究所环境科学专业，获博士学位。主要从事环境健康方向研究。截至2026年1月，已发表/被接收学术论文54篇（第一作者或通讯作者22篇），申请专利2项。现任[International Journal of Environmental Epidemiology]等杂志的编委、[广东省环境诱变剂学会]副监事长等。

[1]. Cong Wan, Huimin Ma*, Xiaowen Zeng*, Guanghui Dong, Jian Chen, Jing You, Fei Cheng, Yuan Luo, Kevin Jones, Gan Zhang, Zhiqiang Yu*, Pingan Peng, DNA methylation of FAM50B/PTCHD3 mediates the relationships between low blood lead exposure and neurobehavioral development of 0-3 aged infants: a prospective birth cohort study in southern China, Environment Health, 2025, https://doi.org/10.1021/envhealth.5c00459 . (IP=6.3)

[2].Huimin Ma,* Haonan Jie, Qianyu Zhang, Cong Wan, Jing You, Guanghui Dong, Xinyu Liu, ZhiqiangYu, Jun Li, and Gan Zhang. Polycyclic nitroaromatic compounds in HULIS as dominant pro-apoptotic agents in PM2.5: Biomass/coal combustion sources, structural insights, and biomarker discovery. Ecotoxicology and Environmental Safety, 2025, 307(15). https://doi.org/10.1016/j.ecoenv.2025.119399 (IP=6.4)

[3].Qianyu Zhang, Huimin Ma,* Jun Li,* Fei liu, Hongxing Jiang, Jinbo Huang,Bin Jiang, Jing You, Guanghui Dong,Qilu Li,Wanli Ma,ZhiqiangYu, and Gan Zhang. Unveiling Condensed Aromatic Amines as Noteworthy Genotoxic Components in PM2.5 Dissolved Organic Matter. Environmental Science & Technology 2025; DOI: 10.1021/acs.est.5c07412 . (IP=11.4，NI指数期刊)（内封面文章）

[4].Qianyu Zhang, Huimin Ma*, Jun Li*, Hongxing Jiang, Wenjing Chena, Cong Wan, Bin Jiang, Guanghui Dong, Xiaowen Zeng, Duohong Chen, Shaoyou Lu, Jing You, Zhiqiang Yu, Xinming Wang, Gan Zhang, Nitroaromatic compounds from secondary nitrate formation and biomass burning are major pro-inflammatory components in organic aerosols in Guangzhou: a bioassay combining high-resolution mass spectrometry analysis, Environmental Science& Technology, 2023, 57(51):21570-21580， https://doi.org/10.1021/acs.est.3c04983 . (IP=11.4，NI指数期刊)（内封面文章）

[5].Cong Wan , Huimin Ma*, Jiahong Liu , Fei Liu, Jing Liu, Guanghui Dong, Xiaowen Zeng, Daochuan Li, Zhiqiang Yu , Xinming Wang, Jun Li, Gan Zhang, Environ. Quantitative relationships of FAM50B and PTCHD3 methylation with reduced intelligence quotients in school aged children exposed to lead: Evidence from epidemiological and in vitro studies. Science Of The Total Environment, 2023.167976, https://doi.org/10.1016/j.scitotenv.2023.

167976.  (IP=10.75)

[6].Huimin Ma*, Wenjing Chen, Qianyu Zhang, Cong Wan, Yangzhi Mo, Fei Liu, Guanghui Dong, Xiaowen Zeng, Duohong Chen, Zhiqiang Yu, Jun Li, Gan Zhang. Pollution source and chemicals structure of the water-soluble fractions in PM2.5 that induce apoptosis in China, Environment International, 173:107820, https://doi.org/10.1016/j.envint.2023.107820 (IP=11.8)

[7].Cong Wan, Shangxia Pan, Lifeng Lin, Jun Li, Guanghui Dong, Kevin C. Jones, Fei Liu, Daochuan Li, Jing Liu, Zhiqiang Yu, Gan Zhang, and Huimin Ma*, DNA Methylation Biomarkers of IQ Reduction are Associated with Long Term Lead Exposure in School Aged Children in Southern China . Environmental Science& Technology, 2021, 55(1): 412–422, http://dx.doi.org/10.1021/acs.est. 0c01696;  (IP=11.4，NI指数期刊)

[8].Yaohui Liang, Liwen Hu, Jun Li, Fei Liu, Kevin C. Jones, Daochuan Li, Jing Liu, Duohong Chen, Jing You, Zhiqiang Yu, Gan Zhang, Guanghui Dong, Huimin Ma*, Short-term personal PM2.5 exposure and change in DNA methylation of imprinted genes: Panel study of healthy young adults in Guangzhou city, China, Environmental Pollution, 2021,15(275):116601, doi: 10.1016/j.envpol.2021. 116601.(IP=8.9)

[9].Huimin Ma, Jun Li, Cong Wan, Yaohui Liang, Xiangyun Zhang, Guanghui Dong, Liwen Hu, Boyi Yang, Xiaowen Zeng, Tao Su, Shaoyou Lu, Shejun Chen, Mahdi Safaei Khorram, Guoying Sheng, Xinming Wang, Bixian Mai, Zhiqiang Yu*, Gan Zhang*， Inflammation response of water-soluble fractions in atmospheric fine particulates: a seasonal observation in 10 large Chinese cities, Environmental Science& Technology. 2019, 53(7):3782-3790. (IP=11.4，NI指数期刊) （内封面文章）

[10].Shangxia Pan, Lifeng Lin, Fan Zeng, Jianpeng Zhang, Guanghui Dong, Boyi Yang, You Jing, Shejun Chen, Gan Zhang, Zhiqiang Yu, Guoying Sheng, Huimin Ma*, Effects of lead, cadmium, arsenic, and mercury co-exposure on children's intelligence quotient in an industrialized area of southern China, Environmental Pollution, 2018, 20(235):47-54. (IP=8.9)

[11].Liudan Zeng, Huimin Ma*, Shangxia Pan, Jing You, Gan Zhang, Zhiqing Yu,  Guoying Sheng, Jiamo Fu，LINE-1 gene hypomethylation and p16 gene hypermethylation in HepG2 cells induced by low-dose and long-term Triclosan exposure: The role of hydroxyl group, Toxicology in vitro, 2016，34:35-44. (IP=3.2)

[12].Junjie Hu, Huimin Ma*, Wenbing Zhang*, Zhiqing Yu, Guoying Sheng, Jiamo Fu，Effects of benzene and its metabolites on global DNA methylation in human normal hepatic L02 cells, Environmental Toxicology. 2014, 29:108-116. (IP=4.35)

[13].Huimin Ma*, Liujin Zheng, Yuhua Li, Shaxia Pan, Zhiqiang Yu, Gan Zhang, Guoying Sheng, Jiamo Fu，Triclosan Reduces the Levels of Global DNA Methylation in HepG2 Cells，Chemosphere, 2013,90:1023-1029. (IP=7.09)

[14].Junjie Hu, Wenbing Zhang*, Huimin Ma*, Yunmei Cai, Guoying Sheng, Jiamo Fu.Simultaneous determination of 8-hydroxy-2 '-deoxyguanosine and 5-methyl-2 '-deoxycytidine in DNA sample by highperformance liquid chromatography/positive electrospray ionization tandem mass spectrometry. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences. 2010, 878:2765-2769.  (IP=3.21)

[15].Huimin Ma, Wenbing Zhang*, Junjie Hu, Zhiqiang Yu, Yong Chen, Qiong luo, Xiaoliu Shi, Yingying Zhang, Renfang Song, Zhen Zhou, Guoying Sheng and Jiamo Fu, “Analysis of global DNA methylation level in human blood using high-performance liquid chromatography/tandem electrospray ionization mass spectrometry (HPLC-ESI-MS/MS)”, European Journal of Mass Spectrometry, 2009,15: 555-561.  (IP=1.3)

[16].Huimin Ma， Wenbing Zhang*， Renfang Song， Huayong Chen， Guoying Sheng， Zhen Zhou and Jiamo Fu, “Characterization of methylated and unmethlyated CpG oligodeoxynucleotides by electrospray ionization tandem mass spectrometry”, European Journal of Mass Spectrometry, 2005,11：581-589；(IP=1.3)

[17].刘家宏，万 聪，潘尚霞 , 马慧敏*，某工业区诱导儿童神经损伤的关键重金属及暴露途径，地球化学，2024，已接收

[18].潘尚霞，马慧敏*，林立丰，张建鹏，万聪，环境铅暴露对儿童智力和精神运动功能影响研究，华南预防医学，2017，5：412-417。

[19].曾柳丹，马慧敏,*, 张干, 于志强, 盛国英，傅家谟， BDE-208和BDE-209诱导了LINE-1基因低甲基化和ESR1基因高甲基化,生态毒理学报，2016，2：163-169。

[20].王晶晶、马慧敏*、李宝才*、郑刘进、潘尚霞、黎玉华、盛国英、傅家谟，苯代谢物氢醌对人体肝细胞内DNA甲基转移酶基因和蛋白表达的影响 ，昆明理工大学学报(自然科学版), 2013,38:90-95.

[21].胡俊杰、马慧敏*、张文兵、李林朋、于志强、盛国英、傅家谟，苯急性暴露对Sprague-Dawley大鼠全基因组DNA 甲基化的影响，生态环境学报,2010, 19(12):2902-2905.

[22].马慧敏，张文兵*，施小六，于志强，胡俊杰，宋任芳，盛国英，傅家谟, “人体结肠癌组织样品中基因组DNA甲基化水平的HPLC-ESI-MS/MS检测”，分析测试学报, 2009, 5:292-296.

[1].国家自然科学面上项目，项目名称：“基于定组人群实验的空气颗粒物有毒污染物筛查及其主要污染源研究”，2025年1月到2028年12月，经费47万，项目号：42477257，课题负责人;

[2].国家自然科学面上项目，项目名称：“大气细颗粒物中类腐殖酸类化合物的有效毒性组分的筛选和鉴定”，2021年1月到2024年12月，经费57万，项目号：42077197，课题负责人;

[3].广州市科技菁英“领航”计划，项目名称“广州市PM2.5中类腐殖酸类化合物（HULIS）诱发炎症与氧化应激的关键化合物筛选”，2025年1月到2027年12月，经费：30万， 课题负责人；

[4]广东省自然科学基金，面上项目， 低浓度血铅暴露对儿童神经发育和智力影响的定量DNA甲基化生物标志物研究，项目号：2025A1515012195， 2025.01-2027.12， 10万，课题负责人；

[5].广东省基础与应用基础研究重大项目，项目名称“大湾区毒害污染物多介质过程与风险管控”，2023年9约- 2028年9月，项目经费：2000万，项目号：2023B0303000007，技术骨干；

[6].国家重点研发计划国合专项，2018YFE0106900，交通源超细颗粒物暴露与神经退行性疾病风险评估的关键技术及应用，2018YFE0106900， 2019年7月至2022年6月，570万，第三课题负责人；

[7].广东省自然科学基金，面上项目，2019A1515011859， 血铅诱导儿童智力降低的DNA甲基化生物标志物的初步鉴定，2019-10至2022-9， 10万，主持人；

[8]. 广州市科技计划项目，项目名称：“广州市PM2.5中不同来源的类腐殖酸类化合物对人体肺细胞的毒性贡献”，2021年3月-2023年3月，经费：5万，主持人。

[9].国家基金重点项目，项目名称 “大气颗粒物中多环芳香有机质（POM）化学组成与毒性的分布和演化”， 2021年1月到2025年12月， 经费：304万，项目号：42030715，技术骨干；

[10].广州市科技计划科学研究专项重点项目，201707020033，广州不同典型区域大气颗粒物中的毒害有机物及毒性效应，2017-5至2020-12, 200万元，技术骨干；

[11].国家自然科学青年基金，21007072， HPLC-MS/MS内标法研究典型污染物对人体DNA甲基化的影响，2011-1至2013-12，19 万元，主持；

[12].中国科学院知识创新工程重要方向项目, KZCX2-YW-GJ02, 南亚POPs污染及其跨境迁移趋向, 2010-1至2012-1, 190万元，第二课题主持人；

[13].中国科学院广州地球化学研究所知识创新领域前沿项目，GIGCX-09-01，苯及其代谢物对人体肝脏和骨髓细胞基因的甲基化影响， 2009-11至2011-11， 20万元，主持人。